Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity
نویسندگان
چکیده
منابع مشابه
Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
Organometallic compounds offer broad scope for the design of therapeutic agents, but this avenue has yet to be widely explored. A key concept in the design of anticancer complexes is optimization of chemical reactivity to allow facile attack on the target site (e.g., DNA) yet avoid attack on other sites associated with unwanted side effects. Here, we consider how this result can be achieved for...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0505798102